Proteona releases CAR T characterization product based on ESCAPETM RNA Sequencing Technology for combined single cell proteomic and transcriptomic analysis
Innovative combined genomic and proteomic analysis platform for Immuno-Oncology and Single Cell BioMedical Applications
SINGAPORE, 10 June 2019 - Proteona Pte. Ltd. today announced the launch of its latest ESCAPETM proteogenomics assay designed specifically for Chimeric Antigen Receptor (CAR) T cell characterization. This is the first commercial product designed to characterize both RNA and protein expression levels across thousands of single CAR T cells. Through the use of simultaneous gene and protein expression analysis, the ESCAPETM CAR T assay is able to identify CAR positive cells, measure changes in cytokine expression, deeply phenotype cells through measuring the expression of 25 key cell surface proteins and discover new gene expression patterns important for your research. Together with Proteona’s state-of-the-art data analysis support, the ESCAPETM CAR T assay provides rich information that can be used at all stages of the CAR T workflow, from initial cell collection to post infusion patient monitoring.
“We are excited about releasing our latest product targeted specifically for researchers, CAR T cell manufacturers, and clinicians to evaluate the link between cell characteristics and clinical outcomes. CAR T and cell therapy in general are the most complex therapeutics in use today, and it is absolutely imperative to study the therapy at the level of the single cell. No other technology can perform such detailed profiling of individual cells. Moreover, by working with Proteona, we help you make sense of the vast amount of data collected,” says Dr. Andreas Schmidt, CEO of Proteona.
“As early adopters of the ESCAPETM CAR T assay, we find it extremely valuable to be able to obtain in depth understanding of CAR T samples on a single cell level,” says Dr. Patrick Schmidt, Principle Investigator at the National Center for Tumor Diseases (NCT) Heidelberg, part of the German Cancer Research Center (DKFZ), who is an expert in CAR T product engineering and manufacturing. “Using only a small amount of blood or bone marrow sample, we get not only an overview of the CAR T cell persistence, but also a snapshot of individual CAR T cell’s activation status and characteristics. This is the most comprehensive tool available both for quality control and for monitoring patient response in clinical studies.”
The Proteona CAR T assay is based on the Enhanced Single Cell Analysis with Protein Expression (ESCAPETM) RNA sequencing technology, which uses DNA-barcoded antibodies to capture proteomic and gene expression data simultaneously at the single cell level. More details about the ESCAPETM platform and the new CAR T product can be found at Proteona’s website, https://proteona.com/.
CAR T cells are a promising therapy against aggressive blood cancers and solid tumors. They are manufactured from T cells, immune cells that are able to recognize specific markers on pathogens or abnormal cells and destroy them. To manufacture CAR T, human T cells are harvested and then modified to target specific cancer antigens, so that they are able to find and kill cancer cells once infused back to the patient. CAR T manufacturing is a complex process, and there is a large range of variations in patient response in terms of toxicity and efficacy. It is still not clear what the mechanisms are that determine the safety and functionality of CAR T cell treatment. The new CAR T ESCAPETM assay now provides the most comprehensive tool to shed light on the complex CAR T mechanisms, opening a new path for the development of safer cell therapies.
The Enhanced Single Cell Analysis with Protein Expression, ESCAPETM
platform, the first commercial service for measuring both gene and protein
expression at the single cell level, is a customizable platform with current
pre-set panels available for measuring multiple cell types.
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Dr Andreas Schmidt
Proteona is a precision medicine company in Singapore, Germany, and the US that is pioneering the use of single cell multi-omics to improve clinical outcomes in cancer. Using a combination of innovative single cell assays and AI-assisted bioinformatics, Proteona enables pharmaceutical companies, biotech partners, and clinicians to integrate single cell level precision into their clinical projects. Proteona continues to develop comprehensive, disease-specific single cell databases combining gene expression, protein expression, and mutation information derived from each individual cells as well as drug response data for each sample. Proteona has been selected as a “One to Watch” by Nature Research Spinoff Award and a Winner of Falling Walls Ventures Breakthrough of the Year 2020. Proteona is a spin-off from the National University of Singapore (NUS) and the Agency for Science, Technology and Research (A*STAR).